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R(+)-BAY K 8644

CAS號	98791-67-4
規格	5mg10mg	純度	98%
貨號	HY-15125	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規格	5mg10mg
純度	98%
貨號	HY-15125
貨期	3天
品牌	Medchemexpress
庫存	---
注意：請務必與賣家聯系核實單價庫存，以確保您的資金安全及交易順利。
參考價：￥1350.00 元/5mg

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貨號	品牌	純度	規格	參考價	貨期
HY-15125	Medchemexpress	98%	5mg10mg	￥1350.00元/5mg	3天

產品詳情

詳細信息(中文)：
Bay-K-8644 ((R)-(_addition_)-)是L型-鈣離子通道激動劑。

詳細信息(英文)：
產品描述：Bay-K-8644 ((R)-(+)-)Bay-K-8644 ((R)-(+)-) is a Ca2+ channel activator; L-type Ca2+ channel activator._x000D_ IC50 value:_x000D_ Target: Ca2+ channel activator_x000D_ S(-)-Bay K 8644 enhanced the peak amplitude of I (Ba) evoked by depolarizing pulses to +10 mV from a holding potential of -70 mV in a concentration-dependent manner (EC(50) = 32 nM), while R(+)-Bay K 8644 inhibited I (Ba) (IC(50) = 975 nM). When R(+)-Bay K 8644 (0.5 microM) was applied, I (Ba) was suppressed to 71 +/- 10% of control. In the presence of R(+)-Bay K 8644 (0.5 microM), additional application of forskolin and sodium nitroprusside (SNP) further inhibited I (Ba) [1]. Ca(2+) sparklets were inhibited by the calcium channel inhibitors R-(+)-Bay K 8644 (1 μM) (0.034 ± 0.02 vs. 0.21 ± 0.08 Hz/mm(2); P