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假尿苷

CAS號	1445-07-4
規格	1KG/袋	純度	99%
貨號	ZM001	貨期	需咨詢
品牌	zhouzyme	庫存	需咨詢
規格	1KG/袋
純度	99%
貨號	ZM001
貨期	---
品牌	zhouzyme
庫存	---
注意：請務必與賣家聯系核實單價庫存，以確保您的資金安全及交易順利。
參考價：￥80.00 元/克

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貨號	品牌	純度	規格	參考價	貨期
ZM001	zhouzyme	99%	1KG/袋	￥80.00元/克	---

產品詳情

詳細信息(中文)：
mRNA疫苗是將含有編碼抗原蛋白的mRNA導入人體，直接進行翻譯，形成相應的抗原蛋白，從而誘導機體產生特異性免疫應答，達到預防免疫的作用。
外源物質mRNA進入人體后，會激活人體的免疫系統，引發由mRNA本身引起的炎癥反應，并可能導致mRNA還未發揮作用就被免疫系統清除。因此，引入天然修飾核苷酸是降低mRNA疫苗免疫原性的有效手段之一。
假尿苷（Pseudouridine）是RNA上最豐富的修飾核苷，又被稱為RNA的“第五種核苷”。2005年，Katalin Karikó等人發現將假尿苷引入RNA中能降低其免疫原性，并且RNA的免疫原性隨著假尿苷引入比例的增高而降低。2008年，Katalin Karikó等人又發現用假尿苷完全替代尿苷的mRNA不僅能極大地降低mRNA的免疫原性，還能提高mRNA的穩定性并增強其翻譯能力。2015年，Oliwia Andries等人發現用N1-甲基假尿苷完全替代尿苷比用假尿苷完全替代尿苷更能降低mRNA的免疫原性，且更能增強mRNA的蛋白表達能力。
基于假尿苷、N1-甲基假尿苷的優秀表現，和市場供應受限的現狀，河北周酶利用自身技術優勢，潛心研發并順利將假尿苷、N1-甲基假尿苷產業化，成功解決原料受限這一難題。若您對產品有興趣，歡迎隨時溝通。

詳細信息(英文)：
mRNA vaccines introduce mRNA encoding antigenic proteins into the body, which undergo direct translation to form corresponding antigenic proteins, thereby inducing a specific immune response in the body to achieve the effect of preventive immunity.

Upon entry of exogenous mRNA into the body, it activates the immune system, triggering inflammatory reactions caused by the mRNA itself, and may lead to clearance of the mRNA before it can exert its effect. Therefore, introducing naturally modified nucleotides is one of the effective means to reduce the immunogenicity of mRNA vaccines.

Pseudouridine is the most abundant modified nucleotide on RNA, also known as the "fifth nucleotide" of RNA. In 2005, Katalin Karikó and others discovered that introducing pseudouridine into RNA can reduce its immunogenicity, and the immunogenicity of RNA decreases with increasing proportions of pseudouridine. In 2008, Katalin Karikó and others found that using pseudouridine to completely replace uridine in mRNA not only greatly reduces the immunogenicity of mRNA but also enhances its stability and translation ability. In 2015, Oliwia Andries and others found that using N1-methyl pseudouridine to completely replace uridine can further reduce the immunogenicity of mRNA and enhance its protein expression ability compared to using pseudouridine alone.

Based on the excellent performance of pseudouridine and N1-methyl pseudouridine, as well as the limited market supply, Hebei Zhou Enzyme has utilized its own technological advantages to focus on research and development and successfully industrialized pseudouridine and N1-methyl pseudouridine, effectively solving the problem of limited raw materials. If you are interested in our products, please feel free to communicate with us at any time.