劉磊，男，1981年生，教授、博士生導師，山東大學化學與化工學院副院長，

入選國家杰青、國家優青、泰山學者特聘專家、教育部新世紀優秀人才、山東省杰青、山東大學齊魯青年學者

學術任職：任 中國化學會有機化學學科委員會委員（2022-）、 Chin. Chem. Lett.編委（2021-）、《有機化學》青年編委（2019-）

研究方向：仿生不對稱氧化、復雜分子不對稱合成、抗菌金屬藥物化學生物學 

郵箱：leiliu@sdu.edu.cn

課題組英文主頁：http://leiliugroup.com

課題組長期招聘有機合成、金屬有機化學、化學生物學、藥理學、藥物化學、理論計算化學專業的博士后，招聘啟示見：https://www.chem.sdu.edu.cn/info/1285/17324.htm 

簡歷

2012.06-        山東大學    教授、博士生導師

2011.03-2012.04   哈佛大學    博士后  導師：Yoshito Kishi 教授

2006.08-2011.03   匹茲堡大學  博士    導師：Paul Floreancig 教授

2003.09-2006.06   蘭州大學    碩士    導師：王銳 院士

1999.09-2003.06   蘭州大學    本科    

主要研究方向

仿生不對稱氧化（有機合成）

抗菌金屬藥物化學生物學（藥物化學、化學生物學）

主要獎勵和榮譽

國家基金委杰出青年基金（2024）

Asian Core Program (ACP) Lectureship Award（Korea，2023） 

泰山學者特聘專家（2023）

山東省優秀研究生導師（2023）

山東省自然科學二等獎（第一位 2022）

山東省青年科技獎（2022）

山東大學優秀教師（2022）

山東省青創人才引育計劃（2021）

國家基金委優秀青年基金（結題優秀）（2017）

霍英東青年教師基金（2016）

Thieme Chemistry Journal Award ??(2016)

山東省“杰出青年基金”??(2014)

教育部“新世紀優秀人才”（2013）

山東大學齊魯青年學者（2012）

國家優秀自費留學生獎學金（中國駐紐約總領事館）（2010）

中國科學院獎學金（2005）

主要科研成果

山東大學獨立研究工作

2024年

80. Catalytic Enantioselective Hydroxylation of Tertiary Propargylic C(sp³)-H Bonds in Acyclic Systems. Cao, M.^#; Wang, H.^#; Hou, F.; Zhu, Y.; Liu, Q.; Tung, C.-H.; Liu, L.*  J. Am. Chem. Soc. 2024, 146, 18396. link  (Highlighted by ChemistryViews. June 29, 2024 link)

79. Catalytic Asymmetric Access to Structurally Diverse N-Alkoxy Amines via A Kinetic Resolution Strategy. Cao, M.^#; Wang, Z.^#; Hou, F.^#; Liu, X.; Sun, S.; Wang, X.; Liu, L.* JACS Au. 2024, 4, 1935. link

78. Enzymatic and Chemo-catalytic Redox Deracemization: Recent Progress. Wan, Q.*; Wang, Z.; Sun, H.; Song, D.; Wang, X.*; Liu, L.* ChemCatChem. 2024, doi.org/10.1002/cctc.202301757. link

2023年

77. Late-Stage Chemo- and Enantioselective Oxidation of Indoles to C3-Monosubstituted Oxindoles. Li, S.; Liu, X.*; Tung, C.-H.; Liu, L.* J. Am. Chem. Soc. 2023, 145, 27120. link (highlighted by Organic Chemistry Portal link)   

76. Catalytic Asymmetric Oxidation of Amines to Hydroxylamines. Wang, G.; Chen, T.; Jia, K.; Ma, W.; Tung, C.-H.; Liu, L.* J. Am. Chem. Soc. 2023, 145, 22276. link  (Highlighted by Org. Process Res. Dev. 2023, 27,  link)

2022年

75. Hydride Abstraction Initiated Catalytic Stereoselective Intermolecular Bond-Forming Processes. Liu, L.* Acc. Chem. Res. 2022, 55, 3537. link

74. Site- and Enantioselective Manganese-Catalyzed Benzylic C-H Azidation of Indolines. Cao, M.; Wang, H.; Ma, Y.; Tung, C.-H.; Liu, L.* J. Am. Chem. Soc. 2022, 144,  15383. link  (Highlighted by Org. Process Res. Dev. 2022, 26,  link)

73. Practical and Selective Bio-inspired Iron-catalyzed Oxidation of Si-H Bonds to Diversely Functionalized Organosilanols. Li, S.; Li, H.; Tung, C.-H.; Liu, L.* ACS. Catal. 2022, 12, 9143. link       

72. Copper-Catalyzed [3+2+1] Cycloaddition of Akenes with Benzoquinones and Dicarbonyl Compounds via Tandem Oxidative Dicarbofunctionalization/Cyclization Sequence. Du, T.; Li, S.; He, Y.; Long, H.; Liu, X.*; Li, H.-B.*; Liu, L.* Chin. J. Chem. 2022, 40,  1681. (invited contribution to the special issue of "Emerging Investigators in 2022") link     

71. Methane Monooxygenase Mimic Asymmetric Oxidant: Self-Assembling μ-Hydroxo, Carboxylate-Bridged Diiron(III) Catalyzed Enantioselective Dehydrogenation. Guan, H.; Tung, C.-H.; Liu, L.* J. Am. Chem. Soc. 2022, 144,  5976. link

70. Kinetic Resolution of Cyclic Benzylic Azides Enabled by Site- and Enantioselective C(sp3)-H Oxidation. Ye, P.; Feng, A.; Wang, L.; Cao, M.; Zhu, R.; Liu, L.*  Nat. Commun. 2022, 13, 1621. link Highlighted by Synform, 2022, A110. link

69. Design, Synthesis and Biological Evaluation of Novel 1,3,4,9-Tetrahydropyrano[3,4-b] indoles as Potential Treatment of Triple Negative Breast Cancer by Treating PI3K/AKT/mTOR pathway. Qin, J.; Sun, X.; Ma, Y.; Cheng, Y.; Ma, Q.; Jing, W.; Qu, S.*; Liu, L.* Bioorg. Med. Chem. 2022, 33, 116594. link

68. Enantioselective Transfer Hydrogenation of Oxocarbenium Ions Enables Asymmetric Access to α-Substituted 1,3-Dihydroisobenzofurans. Zhou, L.; Jia, K.; Liu, X.*; Liu, L.* Synthesis 2022, 421. link 

2021年

67. Enantioselective Construction of Single and Vicinal All-Carbon Quaternary Stereocenters through Ion Pair Catalyzed 1,6-Conjugate Addition. Zhu, Y.; Wang, H.; Wang, G.; Wang, Z.; Liu, Z.*; Liu, L.* Org. Lett. 2021, 23, 7248. link   

66. Construction of Vicinal Quaternary Carbon Stereocenters Through Diastereo- and Enantioselective Oxidative 1,6-Conjugate Addition. Liu, X.; Zhao, C.; Zhu, R.; Liu, L.* Angew. Chem. Int. Ed. 2021, 60, 18499. link

65. NaO^tBu-catalyzed hydrophosphonylation of δ-CN-δ-aryl-disubstituted para-quinone methides with phosphine oxides. Wang, D.; Kan, L.; Ma, Y.*; Liu, L.* Chin. J. Org. Chem. 2021, 41, 3192. link

64. Kinetic resolution of indolines by asymmetric hydroxylamine formation. Wang, G.; Lu, R.; He, C.; Liu, L.* Nat. Commun. 2021, 12, 2512. link

63. Synthesis of diarylmethanes bearing CF₃- and CN-substituted all-carbon quaternary centers and diarylmalononitriles via cyanation of δ-disubstituted para-quinone methides. Pan, X.; Cao, M.; Li, S.; Wang, H.*; Liu, X.*; Liu, L.* Eur. J. Org. Chem. 2021, 1643. link 

62. Redox deracemization of alpha-substituted 1,3-dihydroisobenzofurans. Chen, X.; Zhao, R.; Liu, Z.; Sun, S.; Ma, Y.; Liu, Q.*; Sun, X.*; Liu, L.* Chin. Chem. Lett. 2021, 32, 2305. link

61. Rational design and synthesis of 6-aryl-6H-benzo[c] chromenes as non-steroidal progesterone receptor antagonists for the use against cancers. Qin, J.; Qu, S.; Cheng, Y.; Pan, G.; Jing, W.; Liu, X.; Sun, X.*; Liu, L.* Bioorg. Med. Chem. 2021, 32, 116003. link

60. Oxidative Kinetic Resolution of Cyclic Benzylic Ethers. Sun, S.; Ma, Y.; Liu, Z.; Liu, L.* Angew. Chem. Int. Ed. 2021, 60, 176. link

59. Nickel(II)-Catalyzed Asymmetric Alkylation of Acyclic Oxocarbenium Ions with Carboxylic Acid Derivatives. Ye, P.; Liu, X.; Wang, G.; Liu, L.* Chin. Chem. Lett. 2021, 32, 1237. link

2020年

58. Site- and Enantio-differentiating C(sp3)–H Oxidation Enables Asymmetric Access to Structurally and Stereochemically Diverse Saturated Cyclic Ethers. Sun, S.; Yang, Y.; Zhao, R.; Zhang, D.*; Liu, L.* J. Am. Chem. Soc. 2020, 142, 19346. link (Highlight by Synfacts)

57. Redox Deracemization of Diarylmethyl Alkynes. Ma, Y.; Liu, X.; Mao, Y.; Huang, J.; Ma, S.*; Liu, L.* Org. Chem. Front. 2020, 7, 2526. link

56. Synthesis of Unsymmetric Triarylmethanes Bearing CF₃-Substituted All-Carbon Quaternary Stereocenters: 1,6-Arylation of delta-Trifluoromethyl Substituted para-Quinone Methides. Ma, Y.; Pang, J.; Pan, X.; Ma, S.*; Liu, X.*; Liu, L.* Synlett 2020, 31, 1619. link

55. Catalytic Enantioselective Alkylation of 2-Alkoxyl-tetrahydrofurans. Liu, X.; Sun, S.; Wang, G.; Bai, Z.; Pang, J.*;  Liu, L.* Org. Chem. Front. 2020, 7, 2202. link

54. Redox Deracemization of Tertiary Stereocenters Adjacent to An Electron-withdrawing Group. Mao, Y.; Wang, Z.; Wang, G.; Zhao, R.; Kan, L.; Pan, X.; Liu, L.* ACS Catal. 2020, 10, 7785. link 

53. Catalytic Asymmetric Synthesis of β,γ-Alkynyl α-Amino Esters via Chemo- and Enantioselective Transfer Hydrogenation. Zhang, L.; Liu, A.; Liu, H.; Wan, R.*; Sun, S.*; Liu, L.* Chin. J. Org. Chem. 2020, 40, 2904. link

52. Aerobic Redox Deracemization of α-Aryl Glycine Esters. Chen, X.; Yan, L.; Zhang, L.; Zhao, C.; Feng, G.; Chen, L.; Sun, S.*; Liu, Q.*; Liu, L.* Tetrahedron Lett. 2020, 61, 152107. link

51. Synthesis of Sterically Hindered α-Aminonitriles through 1,6-Aza-Conjugate Addition of Anilines to δ-Cyano Substituted para-Quinone Methides. Wang, L.; Wang, N.; Qi, Y.; Sun, S.; Liu, X.*; Li, W.*; Liu, L.*Chin. J. Org. Chem. 2020, 40, 3934. link (“慶祝《有機化學》創刊四十周年專輯”約稿）.

50. δ-Cyano substituted para-quinone methides enables access to unsymmetric tri- and tetraarylmethanes containing all-carbon quaternary stereocenters. Qi, Y.; Zhang, F.; Wang, L.; Feng, A.; Zhu, R.; Sun, S.*; Li, W.*;  Liu, L.* Org. Biomol. Chem. 2020, 18, 3522. link 

49. Redox Deracemization of β,γ-Alkynyl α-Amino Esters. Zhang, L.; Zhu, R.; Feng, A.; Zhao, C.; Chen, L.; Feng, G.; Liu, L.* Chem. Sci. 2020, 11, 4444. link 

48. Cross-dehydrogenative coupling enables enantioselective access to CF₃-substituted all-carbon quaternary stereocenters. Pan, X.; Wang, Z.; Kan, L.; Mao, Y.; Zhu, Y.; Liu, L.* Chem. Sci. 2020, 11, 2414. link

47. Synthesis of chiral triarylmethanes bearing all-carbon qyaternary stereocenters: catalytic asymmetric oxidative cross-coupling of 2,2-diarylacetonitriles and (hetero)arenes. Wang, Z.; Zhu, Y.; Pan, X.; Wang, G.; Liu, L.* Angew. Chem. Int. Ed. 2020, 59, 3053. link

2019年

46. Cross-dehydrogenative coupling of 3,6-dihydro-2H-pyrans with 1,3-dicarbonyls and aryl moieties. Feng, G.; Sun, C.; Xin, X.; Wan, R.*, Liu, L.* Tetrahedron Lett. 2019, 60, 1547. link 

45. Oxidative C–H alkylation of naphthoquinones with simple alkenes. Cao, L.; Long, H.; Guan, H.; Bi, Y.; Bi, G.; Huang, H.* Liu, L.* Tetrahedron Lett. 2019, 60, 1268. link 

44. Oxidative C–H alkynylation of 3,6-dihydro-2H-pyrans. Zhao, R.; Feng, G.; Xin, X.; Guan, H.; Hua, J.; Wan, R.*; Li, W.*; Liu, L.* Chin. Chem. Lett. 2019, 30, 1432. link 

43. Cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles. Cao, M.; Mao, Y.; Huang, J.; Ma, Y.*; Liu, L.* Tetrahedron Lett. 2019, 60, 1075. link

42. Direct oxidative C(sp³)–H cyanation of secondary benzylic ethers. Wang, Z.; Mao, Y.; Guan, H.; Cao, M.; Hua, J.; Feng, L.*; Liu, L.* Chin. Chem. Lett. 2019, 30, 1241. link

41. Bimolecular oxidative C-H alkynylation of α-substituted Isochromans. Mao, Y.; Cao, M.; Pan, X.; Huang, J.; Li, J.; Xu, L.; Liu, L.* Org. Chem. Front. 6, 2028. link

40. Iron-catalyzed aerobic dehydrogenative kinetic resolution of cyclic secondary amines. Lu, R.; Cao, L.; Guan, H.; Liu, L.* J. Am. Chem. Soc. 2019, 141, 6318. link 

39. Catalytic enantioselective cross-dehydrogenative coupling of 3,6-dihydro-2H-pyrans with aldehydes. Xin, X.; Pan, X.; Meng, Z.; Liu, X.;  Liu, L.* Org. Chem. Front. 2019, 6, 1448. link

38. Catalytic enantioselective oxidative coupling of saturated ethers with carboxylic acid derivatives. Wang, G.; Xin, X.; Wang, Z.; Lu, G.; Ma, Y.; Liu, L.* Nature Commun. 10.1038/s41467-019-08473-x. link (Featured in Nature Communications Editors' Highlights Webpage)

2018年

37. Three-component oxyarylation of alkenes enables access to C₃-substituted dihydrobenzofurans. Feng, G.; Sun, S.; Liu, G.; Long, H.; Liu, L.* Org. Lett. 2018. 20, 7522. link (Top 20 most downloaded article for Nov 2018)

36. Metal-free three-component oxyalkynylation of alkenes. Li, Y.; Lu, R.; Sun, S.; Liu, L.* Org. Lett. 2018. 20, 6836. link cited in Org. Chem. Highlights. link 

35. Catalytic asymmetric cross-dehydrogenative coupling of 2H-chromenes and aldehydes. Pan, X.; Liu, X.; Sun, S.; Meng, Z.; Liu, L.* Chin. J. Chem. 2018, 36, 1187. link (Dedicated to Professor Xiyan Lu on the occasion of his 90th birthday)

34. Iron(II)-catalyzed site-selective functionalization of unactivated C-H bonds guided by alkoxyl radical. Guan, H.; Sun, S.; Mao, Y.; Chen, L.; Lu, R.; Huang, J.; Liu, L.* Angew. Chem. Int. Ed. 2018, 57, 11413. link

33. Copper-catalyzed oxidative cross-dehydrogenative coupling of 2H-chromenes and terminal alkynes. Yang, F.; Li, Y.; Floreancig, P. E.*; Li, X.*; Liu, L.* Org. Biomol. Chem. 2018, 16, 5144. link

32. 飽和開鏈醚的氧化碳氫炔基化研究. Guan, H.; Chen, L.; Liu, L.* Acta Chimica Sinica 2018, 76, 440. (invited contribution)

31. Redox deracemization of 1,3,4,9-tetrahydropyrano[3,4-b]indoles. Lu, R.; Li, Y.; Zhao, J.; Li, J.; Wang, S.; Liu, L.* Chem. Commun. 2018, 54, 4445. link 

30. Direct Oxidative C-H Alkynylation of N-Carbamoyl Tetrahydroisoquinolines and Dihydroisoquinolines. Chen, L.; Sun, C.; Feng, G.; Cao, M.; Zhao, S.; Yan, J.; Wan, R.*; Liu, L.* Org. Biomol. Chem. 2018, 16, 2792. link

29.  A novel tetrahydroisoquinoline (THIQ) analogue induces mitochondria-dependent Apoptosis. Sun, X.; Liu, M.; Gao, L.; Mao, Y.; Zhao, D.; Zhang, J.; Liu, L.* Eur. J. Med. Chem. 2018, 150, 719. link

28. Efficient Access to Chiral Benzo[c]chromenes via Asymmetric Transfer Hydrogenation of Ketals. Li, Y.; Wan, M.; Sun, S.; Fu, Z.; Huang, H.; Liu, L.* Org. Chem. Front. 2018, 5, 1280. link

2017年

27. Oxidative C-H functionalization of N-carbamoyl 1,2-Dihydroquinolines. Liu, Z.; Chen, L.; Li, J.; Liu, K.; Zhao, J.; Xu, M.; Feng, L.; Wan, R.; Li, W.; Liu, L.* Org. Biomol. Chem. 2017, 15, 7600. link

26. Regio- and Diastereoselective Cross-Dehydrogenative Coupling of Tetrahydropyridines with 1,3-Dicarbonyl Compounds. Long, H.; Wang, G.; Lu, R.; Xu, M.; Zhang, K.; Qi, S.; He, Y.; Bu, Y.; Liu, L.* Org. Lett. 2017, 19, 2146. link

25. Organocatalytic Redox Deracemization of Cyclic Benzylic Ethers Enabled by An "Acetal Pool" Strategy. Wan, M.; Shu, S.; Li, Y.; Liu, L.* Angew. Chem. Int. Ed. 2017, 56, 5116. link (Highlight by Synfacts)

2016年

24. Wang, G.; Mao, Y.; Liu, L.* Diastereoselectively Complementary C-H Functionalization Enables Access to Structurally and Stereochemically Diverse 2,6-Substituted Piperidines. Org. Lett. 2016,18, 6476. link

23. Wang, G.; Sun, S.; Mao, Y.; Xie, Z.; Liu, L.* Chromium (II) Catalyzed Enantioselective Arylation of Ketones. Beilstein. J. Org. Chem. 2016, 12, 2771. link (Invited by Professor Tehshik P Yoon for Thematic Series "Strategies in Asymmetric Synthesis")

22. Sun, Y.; Wang, G.; Chen, J.; Liu, C.; Cai, M.; Zhu, R.*; Huang, H.*; Li, W.*; Liu, L.* A Practical Oxidative C-H Functionalization of N-Carbamoyl Tetrahydro-beta-Carbolines with Diverse Potassium Trifluoroborates. Org. Biomol. Chem. 2016, 14, 9431. link

21. Xie, Z.; Zan, X.; Sun, S.; Pan, X.; Liu, L.* Organocatalytic Enantioselective Cross-Dehydrogenative Coupling of N-Carbamoyl Cyclic Amines with Aldehydes. Org. Lett. 2016, 18, 3944. link

20. Xie, Z.; Liu, X.; Liu, L.* Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes. Org. Lett. 2016, 18, 2982. link (Highlight by Synfacts)

19. Sun, S.; Liu, L.* Catalytic Enantioselective Alkynylation of Tetrahydroisoquinoline-Based N-Acyl Hemiaminals. Synthesis 2016, 48, 2627. link (Invited for specific topic "Asymmetric Synthesis" by Erick Carreira)

18. Xie, Z.; Jia, J.; Liu, X.; Liu, L.* Copper(II) Triflate-Catalyzed Aerobic Oxidative C-H Functionalization of Glycine Derivatives with Olefins and Organoboranes. Adv. Synth. Catal. 2016, 358, 919. link 

17. Liu, G.; Qian, J.; Hua, J.; Cai, F.; Li, X.; Liu, L.* An Economical Synthesis of Substituted Quinoline-2-Carboxylates through the Potassium Persulfate-Mediated Cross-Dehydrogenative Coupling of N-Aryl Glycine Derivatives with Olefins. Org. Biomol. Chem. 2016, 14, 1147. link

2015年

16. Chen.J.; Wan, M.; Hua, J.; Sun, Y.; Lv, Z.; Li, W.*; Liu, L.* TBHP/TFA Mediated Oxidative Cross-Dehydrogenative Coupling of N-Heterocycles with Aldehydes. Org. Biomol. Chem. 2015, 13, 11561. link (Highlight by Synfacts)

15. Wan, M.; Lou,H.; Liu, L.* C1-Benzyl and benzoyl isoquinoline synthesis throughdirect oxidative cross-dehydrogenative coupling with methyl arenes. Chem. Commun. 2015, 51, 13953. link (Highlight by Synfacts)  

14. Sun, S.; Mao,Y.; Lou, H.; Liu, L.* Copper(II)/amine synergisticallycatalyzed enantioselective alkylation of cyclic N-acyl hemiaminals withaldehydes. Chem. Commun. 2015, 51, 10691. link

13. Liu, X.; Sun,S.; Meng, Z.; Lou, H.; Liu, L.* Organocatalytic asymmetricC-H vinylation and arylation of N-acyl tetrahydroisoquinolines. Org. Lett. 2015, 17, 2396. link (Top 20 most downloaded article for May2015)

12. Li, F.; Meng,Z.; Hua, J.; Li, W.; Lou, H.; Liu, L.* Indium-catalyzedoxidative cross-dehydrogenative coupling of chromenes with 1,3-dicarbonyls andaryl rings. Org. Biomol. Chem. 2015, 13, 5710. link

11. Sun, S.; Li,C.; Floreancig, P. E.; Lou, H.; Liu, L.* Highly enantioselectivecatalytic cross-dehydrogenative coupling of N-carbamoyl tetrahydro isoquino-lines and terminal alkynes. Org. Lett. 2015, 17, 1684. link (Highlight by Synfacts)

10. Liu, X.;Meng, Z.; Li, C.; Lou, H.; Liu, L.* OrganocatalyticEnantioselective Oxidative C-H Alkenylation and Arylation of N-CarbamoylTetrahydropyridines and Tetrahydro-β-Carbolines. Angew. Chem. Int. Ed. 2015, 54,6012. link (Highlight by Synfacts, cited in Org. Chem. Highlights) link

2014年

9. Chen, W.;Xie, Z.; Zheng, H.; Lou, H.*; Liu, L.* Structurally Diverseα-Substituted Benzopyran Synthesis through A Practical Metal-Free C(sp³)-HFunctionalization. Org. Lett. 2014, 16, 5988. link

8. Sun, S.; Yang,J.; Li, F.; Lv, Z.; Li, W.*; Lou, H.*; Liu, L.* Seven- and Eight-MemberedHeterocyclic Biaryl Synthesis through A Metal-Free Oxidative Coupling Reaction.Tetrahedron Lett. 2014, 55, 6899. link

7. Wan, M.; Meng,Z.; Lou, H.; Liu, L.* Practical and Highly Selective C-H Functionalizationof Structurally Diverse Ethers. Angew. Chem. Int. Ed. 2014, 53,13845. link (Selected as “hot paper” by Angew Chem)

6. Yang, J.; Sun, S.; Zeng, Z.; Zheng, H.; Lou, H.; Liu, L.* An economic and Environmentally Friendly Oxidative Biaryl Coupling Promoted byActivated MnO₂. Org. Biomol. Chem. 2014, 12,7774. link

5. Pan, X. H.;Hu, Q. W.; Chen, W. F.; Liu, X. G.; Sun, B.; Huang, Z. L.; Zeng, Z. Y.; Wang,L. G.; Zhao, D.; Ji, M.; Liu, L.*; Lou, H.* Copper(II) CatalyzedCross-Dehydrogenative Coupling of Cyclic Benzylic Ethers with Simple Carbonyl Compoundsby Na₂S₂O₈. Tetrahedron 2014, 70,3447. link

4. Chen, W. F.;Zheng, H. B.; Pan, X. H.; Xie, Z. Y.; Zan, X.; Sun, B.; Liu, L.*;Lou, H.* A Metal-Free Cross-Dehydrogenative Coupling of N-Carbamoyl Tetrahydroispquinolineby Sodium Persulfate. Tetrahedron Lett. 2014, 55, 2879. link

3. Xie, Z. Y.; Liu, L.*; Chen, W. F.; Zheng, H. B.; Xu, Q. Q.; Yuan, H. Q.; Lou, H.* PracticalMetal-Free C(sp3)-H Functionalization: Construction of Structurally Diverse a-SubstitutedN-Benzyl and N-Allyl Carbamates. Angew. Chem. Int. Ed. 2014, 53,3904. link (Highlight by Chinese J Org Chem)

2. Meng, Z. L.; Sun, S. T.; Yuan, H. Q.; Lou, H. X.*; Liu, L.* Catalytic Enantioselective Oxidative Cross-Coupling of Benzylic Ethers withAldehydes. Angew. Chem. Int. Ed. 2014, 53, 543. link (selectedas “Hot Paper” by AngewChem/Highlightby Synfact, 2014, 341)

2013年

1. Liu, X. G.; Sun, B.; Xie, Z. Y.; Qin, X. J.; Liu, L.*; Lou, H. X.* Manganese dioxide-Methanesulfonic Acid Promoted Direct DehydrogenativeAlkylation of sp³ C–H Bonds Adjacent to A Heteroatom. J. Org. Chem. 2013, 78, 3104. link

哈佛大學博士后研究工作（2011-2012）

13. Liu, L.;Henderson, J. A.; Yamamoto, A.; Brémond, P.; Kishi, Y. Synthesis of alcoholsfrom m-Fluorophenylsulfones and Dialkylboranes: Application to theC14-C35 Building Block of E7389. Org. Lett. 2012, 14,2262. 

匹茲堡大學攻讀博士期間工作（2006-2011）
12. Liu,L.; Floreancig, P. E. Stereoselective Synthesis of Tertiary Ethersthrough Geometrical Control of Highly Substituted Oxocarbenium Ions. Angew. Chem. Int. Ed. 2010, 49, 5894. (Highlighted in SynFacts2010, 1152 and Synstory 2010, A101)

11. Liu, L.; Floreancig, P. E. Structurally and Stereochemically Diverse TetrahydropyranSynthesis through Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 2010, 49, 3069. (Selected as “Hot Paper” in Angew.Chem. Int. Ed.)

10. Liu, L.; Floreancig, P. E. Stereoselective Heterocycles Synthesis through OxidativeCarbon–Hydrogen Bond Activation. Curr. Opin. Drug. Discov. Devel. 2010,13, 733.

9. Liu, L.;Floreancig, P. E. DDQ-Catalyzed Reactions Employing MnO₂ as A StoichiometricOxidant. Org. Lett. 2010, 12, 4686.

8. Liu, L.;Floreancig, P. E. Cyclization Reactions through DDQ-Mediated Vinyl OxazolidinoneOxidation. Org. Lett. 2009, 11, 3152. (Highlightedin SynFacts 2009, 998)

7. Tu, W.; Liu,L.; Floreancig, P. E. Diastereoselective Tetrahydropyrone Synthesis throughTransition-Metal-Free Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 2008, 47, 4184.

蘭州大學攻讀碩士期間工作（2003-2006）

6. Liu, L.;Wang, R.; Kang, Y.-F.; Cai, H.-Q.; Chen, C. Highly Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Bis(hydroxycamphorsulfonamide)-copper(II) Complex. Synlett. 2006, 8, 1245.

5. Liu, L.;Wang, R.; Kang, Y.-F.; Chen, C.; Xu, Z.-Q.; Zhou, Y.-F.; Ni, M.; Cai, H.-Q.;Gong, M.-Z. Highly Enantioselective Phenylacetylene Addition to Aromatic KetonesCatalyzed by Cinchona Alkaloid-Aluminum Complexes. J. Org. Chem. 2005,70, 1084.

4. Liu, L.;Kang, Y.-F.; Wang, R.; Zhou, Y.-F.; Chen, C.; Ni, M.; Gong, M.-Z. EnantioselectiveAlkynylation of Aromatic Ketones Promoted by (S)-Phenylalanine-derived β-Amino Alcohol. Tetrahedron: Asymmetry 2004, 15, 3757.

3. Kang, Y.-F.; Liu,L.; Wang, R.; Zhou, Y.-F.; Yan, W.-J. Enantioselective Alkynylation ofAromatic Ketones Catalyzed by New Chiral Oxazolidine Ligands. Adv. Synth.Catal. 2005, 347, 243.

2. Kang, Y.-F.; Liu,L.; Wang, R.; Yan, W.-J.; Zhou, Y.-F. The Use of Bifunctional CatalystSystems in the Asymmetric Addition of Alkynylzinc to Aldehydes. Tetrahedron:Asymmetry 2004, 15, 3155.

1. Kang, Y.-F.; Liu,L.; Wang, R.; Ni, M.; Han, Z.-J. Enantioselective Addition of Diethylzincto Aromatic Aldehydes Catalyzed by New Chiral Oxazolidine Ligand. Synth.Commun. 2005, 35, 1819.