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4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid

CAS號	402473-54-5
規格	2mg5mg	純度	98%
貨號	HY-50901	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規格	2mg5mg
純度	98%
貨號	HY-50901
貨期	3天
品牌	Medchemexpress
庫存	---
注意：請務必與賣家聯系核實單價庫存，以確保您的資金安全及交易順利。
參考價：￥850.00 元/2mg

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貨號	品牌	純度	規格	參考價	貨期
HY-50901	Medchemexpress	98%	2mg5mg	￥850.00元/2mg	3天

產品詳情

詳細信息(中文)：
ONO-AE3-208(AE 3-208)是EP4拮抗劑，能抑制前列腺癌細胞侵襲，遷移和轉移。

詳細信息(英文)：
產品描述：ONO-AE3-208ONO-AE3-208(AE 3-208) is an EP4 antagonist; suppresses cell invasion, migration, and metastasis of prostate cancer._x000D_ IC50 value:_x000D_ Target: EP4 _x000D_ EP4 over-expressing LNCaP was established, and their cell invasiveness was compared with the control LNCaP (LNCaP/mock). The in vitro cell proliferation, invasion, and migration of these cells were examined under different concentrations of ONO-AE3-208. An in vivo bone metastatic mouse model was constructed by inoculating luciferase expressing PC3 cells into left ventricle of nude mice. Their bone metastasis was observed by bioluminescent imaging with or without ONO-AE3-208 administration. The EP4 mRNA expression levels were higher in PC3 than in LNCaP, and EP4 over-expression of LNCaP cells enhanced their cell invasiveness. _x000D_ Arachidonic acid caused dose-dependent dilation of the attached Af-Art (from 8.6 ± 1.2 to 15.3 ± 0.7 μm; P

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物理化學性質
英文名	4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid
中文名	4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸
CAS號	402473-54-5	溶解性	---
分子量	404.43400	熔點	---
密度	1.3	沸點	662.36oC at 760 mmHg