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5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine,dihydrochloride

CAS號	1380575-43-8
規格	5mg10mg	純度	98%
貨號	HY-15656A	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規格	5mg10mg
純度	98%
貨號	HY-15656A
貨期	3天
品牌	Medchemexpress
庫存	---
注意：請務必與賣家聯系核實單價庫存，以確保您的資金安全及交易順利。
參考價：￥650.00 元/5mg

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貨號	品牌	純度	規格	參考價	貨期
HY-15656A	Medchemexpress	98%	5mg10mg	￥650.00元/5mg	3天

產品詳情

詳細信息(中文)：
LDK378 2Hcl是ALK抑制劑，IC50為0.2 nM，比對IGF-1R和InsR的抑制性高40倍和35倍。

詳細信息(英文)：
產品描述：LDK378 (dihydrochloride)LDK378 2Hcl (Ceritinib) is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively. _x000D_ IC50 Value: 0.2 nM [1]_x000D_ Target: ALK_x000D_ in vitro: LDK378 shows great anti-proliferative activity in Ba/F3-NPM-ALK and Karpas290 cells with IC50 of 26.0 nM and 22.8 nM, compared with IC50 of 319.5 nM and 2477 nM in Ba/F3-Tel-InsR and Ba/F3-WT cells [1]._x000D_ in vivo: LDK378 is designed to reduce the possibility of forming reactive metabolites and shows undetectable levels of glutathione (GSH) adducts (

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物理化學性質
英文名	5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine,dihydrochloride
中文名	5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine,dihydrochloride
CAS號	1380575-43-8	溶解性	---
分子量	631.05700	熔點	---
密度	---	沸點	---