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2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid

CAS號	1166827-44-6
規(guī)格	2mg5mg	純度	98%
貨號	HY-15497	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規(guī)格	2mg5mg
純度	98%
貨號	HY-15497
貨期	3天
品牌	Medchemexpress
庫存	---
注意：請務(wù)必與賣家聯(lián)系核實(shí)單價(jià)庫存，以確保您的資金安全及交易順利。
參考價(jià)：￥1897.00 元/2mg

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貨號	品牌	純度	規(guī)格	參考價(jià)	貨期
HY-15497	Medchemexpress	98%	2mg5mg	￥1897.00元/2mg	3天

產(chǎn)品詳情

詳細(xì)信息(中文)：
AZD7687是hDGAT1抑制劑，IC50為80 nM。

詳細(xì)信息(英文)：
產(chǎn)品描述：AZD7687AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1)._x000D_ IC50 value: 80 nM [1]_x000D_ Target: DGAT1_x000D_ in vitro: Plasma AZD7687 exposure was measured repeatedly. Postprandial serum TAG excursion was measured during 8 h after a standardized mixed meal with fat energy content of 60% (SMM 60%; five cohorts, 1-20 mg), before (baseline) and after dosing, to assess effects on gut DGAT1 activity. AZD7687 markedly reduced postprandial TAG excursion with a steep concentration-effect relationship [2]._x000D_ in vivo: Multiple doses of AZD7687 (1, 2.5, 5, 10 and 20 mg/day, n=6 or n=12 for each) or placebo (n=20) were administered for 1 week. Dose-dependent reductions in postprandial serum TAG were demonstrated with AZD7687 doses ≥5mg compared with placebo (p

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物理化學(xué)性質(zhì)
英文名	2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid
中文名	2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid
CAS號	1166827-44-6	溶解性	---
分子量	367.44200	熔點(diǎn)	---
密度	---	沸點(diǎn)	---