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(R)-N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide

(R)-N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide

CAS號 1133432-49-1
規格 2mg5mg
純度 98%
貨號 HY-15427
貨期 3天
品牌 Medchemexpress
庫存 ---
注意：請務必與賣家聯系核實單價庫存，以確保您的資金安全及交易順利。
參考價： ￥2333.00 元/2mg
貨號 品牌 純度 規格 參考價 貨期
HY-15427 Medchemexpress 98% 2mg5mg ￥2333.00元/2mg 3天

產品詳情

詳細信息(中文)：
GDC-0834是高效BTK抑制劑，在體外生化和細胞實驗中IC50分別為5.9和6.4 nM。
詳細信息(英文)：
產品描述：GDC-0834GDC-0834 is a potent and selective BTK inhibitor with in vitro IC50s of 5.9 and 6.4 nM in biochemical and cellular assays, respectively._x000D_ IC50 value: 5.9 nM/6.4 nM(biochemical/cellular assay) [1]_x000D_ Target: BTK_x000D_ in vitro: GDC-0834 inhibited BTK with an in vitro IC(50) of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC(50) of 1.1 and 5.6 μM in mouse and rat, respectively [1]._x000D_ in vivo: Administration of GDC-0834 (30-100 mg/kg) in a rat collagen-induced arthritis (CIA) model resulted in a dose-dependent decrease of ankle swelling and reduction of morphologic pathology [1]. GDC-0834 exhibited low clearance in PXB chimeric mice with humanized liver. Uncertainty in human pharmacokinetic prediction and high interest in a BTK inhibitor for clinical evaluation prompted an investigational new drug strategy, in which GDC-0834 was rapidly advanced to a single-dose human clinical trial. GDC-0834 plasma concentrations in humans were below the limit of quantitation (

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英文名 (R)-N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide
中文名 ---
CAS號 1133432-49-1 溶解性 ---
分子量 596.74200 熔點 ---
密度 --- 沸點 ---

商家信息

上海皓元生物醫藥科技有限公司

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  • 公司類型：研發型
  • 成立時間：2009-03-17
  • 所在地區：上海市市轄區
  • 注冊資本：300萬元
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