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撲爾敏

CAS號(hào) 113-92-8
規(guī)格 25kg/紙板桶（根據(jù)客戶要求包裝）
純度 99%
貨號(hào) 39086
貨期 3天
品牌 艾寧泰
庫(kù)存 680kg
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參考價(jià)： ￥1.00 元/公斤
貨號(hào) 品牌 純度 規(guī)格 參考價(jià) 貨期
39086 艾寧泰 99% 25kg/紙板桶（根據(jù)客戶要求包裝） ￥1.00元/公斤 3天

產(chǎn)品詳情

詳細(xì)信息(中文)：
撲爾敏

中文別名：馬來(lái)那敏；撲爾敏; 馬來(lái)酸氯苯吡胺; 氯屈米通; 馬來(lái)酸氯苯那敏;
英文名稱：Chlorphenamine Maleate
英文別名：chlorphenamine hydrogen maleate
CAS 號(hào)：113-92-8
化學(xué)名:N,N-二甲基-γ-(4-氯苯基)-2-吡啶丙胺順丁烯二酸鹽
分 子 式：C20H23ClN2O4
分子量：390.86
含量：99%
熔點(diǎn)：130-135 °C(lit.)
儲(chǔ)存條件：-20°C Freezer
水溶解性：1-5 g/100 mL at 21 oC
類別：抗變態(tài)反應(yīng)用藥

化學(xué)性質(zhì)：白色結(jié)晶性粉末。熔點(diǎn)131-135℃。易溶于水、乙醇、氯仿，微溶于乙醚、無(wú)臭、味苦。
包裝：25公斤/桶。
用途：用作抗過(guò)敏藥
用途：該品抗組織胺作用超過(guò)苯海拉明和異丙嗪，用量小，副作用輕。用于蕁麻疹、血管舒張性鼻炎、感冒、哮喘、鼻炎、接觸性皮炎，也用于藥物和食物等引起的過(guò)敏癥、蟲咬及暈動(dòng)等。
用途：抗組織胺藥。與氯屈米通相類似，溴苯吡胺也中抗組織胺藥。溴苯吡胺的生產(chǎn)方法也與氯屈米通相類似，只不過(guò)將起始原料用溴苯化合物代替。

生產(chǎn)方法：由2-對(duì)氯芐基吡啶經(jīng)兩步縮合而得。在干燥的反應(yīng)鍋內(nèi)，加入氨鈉、無(wú)水甲苯，加熱至回流，將2-對(duì)氯芐基吡啶和溴代乙醛縮二乙醇同時(shí)滴入。加畢，回流反應(yīng)8h。冷卻靜置，取甲苯液，固體物用少量水溶解后以甲苯提取。將提取液與甲苯液合并，水洗至中性，回收甲苯，得3-對(duì)氯苯-3-（2-吡啶基）-丙醛縮二乙醇。將其與DMF混勻加入反應(yīng)鍋，攪拌下加入甲酸與水的混合液。加熱至110-120℃反應(yīng)2h，150-160℃反應(yīng)3h。冷卻，減壓回收DMF，加熱水稀釋，用堿液調(diào)至pH14。然后用甲苯提取，用水洗提取液至中性，回收甲苯后減壓蒸餾，收集150-190℃餾分，得氯屈米通。
詳細(xì)信息(英文)：
chlorpheniramine

Chinese alias: melamine; chlorpheniramine; chlorpheniramine maleate; chlorhexidine; chlorpheniramine maleate;
English name: Chlorphenamine Maleate
English alias: chlorphenamine hydrogen maleate
CAS Number: 113-92-8
Chemical name: N,N-dimethyl-γ-(4-chlorophenyl)-2-pyridinepropylamine maleate
Molecular Formula: C20H23ClN2O4
Molecular weight: 390.86
Content: 99%
Melting point: 130-135 °C (lit.)
Storage condition: -20°C Freezer
Water solubility: 1-5 g/100 mL at 21 oC
Category: Anti-allergy medication

Chemical properties: White crystalline powder. 131-135°C. Soluble in water, ethanol, chloroform, slightly soluble in ether, odorless, bitter taste.
Packing: 25 kg/barrel.
Uses: Used as anti-allergic drugs
Uses: The product anti-histamine effect than diphenhydramine and promethazine, the amount of small, side effects are light. For urticaria, vasodilator rhinitis, colds, asthma, rhinitis, contact dermatitis, but also for allergies caused by drugs and food, insect bites and motion sickness.
Uses: Antihistamines. Similar to chlorhexidine, bromophenylamine is also an antihistamine. Bromopyramide is also produced in a similar manner as chlorotrimetrazine, except that the starting material is replaced by a bromobenzene compound.

Production methods : from 2-chlorobenzyl pyridine derived by two-step condensation. In a dry reaction vessel, ammoniacal sodium and anhydrous toluene were added, heated to reflux, and 2-p-chlorobenzylpyridine and bromoacetaldehyde diethyl acetal were simultaneously added dropwise. After the addition, reflux reaction 8h. After cooling, the toluene solution was taken and the solid matter was dissolved in a small amount of water and extracted with toluene. The extract was combined with toluene, washed with water to neutrality, and toluene was recovered to give 3-p-chlorobenzene-3-(2-pyridyl)-propionaldehyde diethyl acetal. Mix it with DMF and add it to the reaction pot. Add a mixture of formic acid and water under stirring. The reaction w

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英文名 Chlorpheniramine maleate
中文名 撲爾敏
CAS號(hào) 113-92-8 溶解性 1-5 G/100 ML AT 21 oC
分子量 390.86100 熔點(diǎn) 130-135?°C(lit.)
密度 1.107 g/cm3 沸點(diǎn) 379oC at 760 mmHg

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